Total synthesis of (.+-.)-ligantrol, a linear polyoxygenated diterpene.

Total synthesis of polyoxygenated cembrenes.

Total synthesis of the Isodon diterpene sculponeatin N.

The total synthesis of sculponeatin N, a bioactive polycyclic diterpene isolated from Isodon sculponeatus, is reported. Key features of the synthesis include diastereoselective Nazarov and ring-closing metathesis reactions, and a highly efficient formation of the bicyclo[3.2.1]octane ring system by a reductive radical cyclization.

Synthesis of ent-kaurane diterpene monoglycosides.

Synthesis of two ent-kaurane diterpene glycosides, steviol 19-O-β-D-glucopyranosiduronic acid (steviol glucuronide, 5), and 13-hydroxy ent-kaur-16-en-19-oic acid-β-D-glucopyranosyl ester (7) has been achieved from a common starting material, steviol, using phase transfer catalyst. Also, synthesis of an additional 17-nor-ent-kaurane glycoside, namely 13-methyl-16-oxo-17-nor-ent-kauran-19-oic aci...

Synthesis and Biological Evaluation of 3,16,20-Polyoxygenated Steroids of Marine Origin and Their Analogs

The natural polyoxygenated steroids (20S)-20-hydroxycholestane-3,16-dione (1), (16S, 20S)16,20-dihydroxycholestan-3-one (2), (20S)-20-hydroxycholest-1-ene-3,16-dione (3) and (20S)-20hydroxycholest-4-ene-3,16-dione (4), isolated from the gorgonian, Leptogorgia sarmentosa and unnatural analogs (5) (6), (12) and (13) were synthesized from tigogenin. Antitumor activity against three tumor cell line...

Synthesis and sensory evaluation of ent-kaurane diterpene glycosides.

Catalytic hydrogenation of the three ent-kaurane diterpene glycosides isolated from Stevia rebaudiana, namely rubusoside, stevioside, and rebaudioside-A has been carried out using Pd(OH)₂ and their corresponding dihydro derivatives have been isolated as the products. Synthesis of reduced steviol glycosides was performed using straightforward chemistry and their structures were characterized on ...